P6273
2-Propylpentanoic acid
동의어(들):
Valproic acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
(CH3CH2CH2)2CHCO2H
CAS 번호:
Molecular Weight:
144.21
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
EC Number:
202-777-3
MDL number:
InChI key
NIJJYAXOARWZEE-UHFFFAOYSA-N
InChI
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
SMILES string
CCCC(C(O)=O)CCC
refractive index
n20/D 1.425 (lit.)
bp
220 °C (lit.)
solubility
H2O: slightly soluble
alcohol: soluble
density
0.9 g/mL at 25 °C (lit.)
lipid type
saturated FAs
Quality Level
Gene Information
human ... ALDH5A1(7915), CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)
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Application
2-Propylpentanoic acid has been used as a supplement in mouse embryonic fibroblast - conditioned medium (MEF-CM) to feed the cells.
Biochem/physiol Actions
2-Propylpentanoic acid is a short-chain fatty acid and potentially inhibits histone deacetylase action. It is known to promote tumor cell toxicity and increase susceptibility to radiation. 2-Propylpentanoic acid elevates the levels of γ-aminobutyric acid in the brain. Reduced central nervous system action is observed in overdosage of 2-propylpentanoic acid. It enhance the inhibitory action of γ-aminobutyric acid (GABA) by blocking voltage-dependent sodium channel.
Anticonvulsant that also has efficacy as a mood stabilizer in bipolar disorder
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
231.8 °F - closed cup
flash_point_c
111 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Bonan Zhong et al.
Stem cells and development, 20(5), 795-807 (2010-11-10)
Induced pluripotent stem (iPS) cells have great potential for regenerative medicine and gene therapy. Thus far, iPS cells have typically been generated using integrating viral vectors expressing various reprogramming transcription factors; nonintegrating methods have been less effective and efficient. Because
Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell linesin vitro
Cuijie S, et al.
Chinese Medical Journal (English Edition), 125(24), 4338-4343 (2012)
Efficient generation of nonhuman primate induced pluripotent stem cells
Zhong B, et al.
Stem Cells and Development, 20(5), 795-807 (2010)
3-Heptanone as a potential new marker for valproic acid therapy
Erhart S, et al.
Journal of Breath Research, 3(1), 016004-016004 (2009)
Irma Virant-Klun et al.
Cells, 8(7) (2019-07-25)
A population of small stem cells with diameters of up to 5 μm resembling very small embryonic-like stem cells (VSELs) were sorted from human embryonic stem cell (hESC) cultures using magnetic-activated cell sorting (MACS) based on the expression of a
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