P6777
Phenelzine sulfate salt
synthetic, ≥98% (iodine, titration), MAO-A/B inhibitor, powder
동의어(들):
Phenelzine hydrogen sulphate
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C8H12N2 · H2O4S
CAS 번호:
Molecular Weight:
234.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-856-0
MDL number:
제품 이름
Phenelzine sulfate salt,
biological source
synthetic
Quality Level
assay
≥98% (iodine, titration)
form
powder
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES string
NNCCC1=CC=CC=C1.OS(=O)(O)=O
InChI
1S/C8H12N2.H2O4S/c9-10-7-6-8-4-2-1-3-5-8;1-5(2,3)4/h1-5,10H,6-7,9H2;(H2,1,2,3,4)
InChI key
RXBKMJIPNDOHFR-UHFFFAOYSA-N
Gene Information
human ... MAOA(4128), MAOB(4129)
Biochem/physiol Actions
Non-selective MAO-A/B inhibitor.
Features and Benefits
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Darrick T Balu et al.
Brain research, 1211, 37-43 (2008-04-25)
Antidepressant treatments have been proposed to produce their therapeutic effects, in part, through increasing neurotrophin levels in the brain. The current experiments investigated the effects of acute and chronic treatment with different pharmacologic and somatic antidepressant treatments on protein levels
Françoise Chiche et al.
Molecular pharmacology, 75(5), 1052-1061 (2009-02-10)
Change in body weight is a frequent side effect of antidepressants and is considered to be mediated by central effects on food intake and energy expenditure. The antidepressant phenelzine (Nardil) potently inhibits both monoamine oxidase and semicarbazide-sensitive amine oxidase activities
Anna Z Antosik-Wójcińska et al.
Psychiatria polska, 47(1), 127-134 (2013-07-31)
The use of non-selective monoamine oxidase inhibitors (IMAO) may be associated with the risk of addiction, which is confirmed by case studies published so far. Harmful use of antidepressants in patients with affective disorders and anxiety is not frequent, but
Hwan-Suck Chung et al.
Neurochemical research, 37(10), 2117-2124 (2012-07-06)
Phenelzine is a potent monoamine oxidase inhibitor that is used in patients with depression. It is also well known that nitric oxide (NO) synthase inhibitors show preclinical antidepressant-like properties, which suggests that NO is involved in the pathogenesis of depression.
The antidepressant phenelzine protects neurons and astrocytes against formaldehyde-induced toxicity.
Mee-Sook Song et al.
Journal of neurochemistry, 114(5), 1405-1413 (2010-06-19)
Reactive aldehydes have been implicated in the etiology of several neurological and psychiatric disorders, and there is considerable interest in drugs to counteract the actions of these aldehydes. Increased formaldehyde (FA) and up-regulation of semicarbazide-sensitive amine oxidase, which forms FA
문서
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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