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Merck

P8688

(S)-(−)-Propranolol hydrochloride

≥98% (TLC), β1- and β2-aadrenergic receptor blocker, powder

동의어(들):

(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
C10H7OCH2CH(OH)CH2NHCH(CH3)2·HCl
CAS 번호:
4199-10-4
Molecular Weight:
295.80
NACRES:
NA.77
PubChem Substance ID:
24278657
UNSPSC Code:
12352200
EC Number:
224-096-0
MDL number:
MFCD00064547
Beilstein/REAXYS Number:
3574966
Assay:
≥98% (TLC)
Form:
powder
Quality level:
200

주요 문서

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제품 이름

(S)-(−)-Propranolol hydrochloride, ≥98% (TLC), powder

InChI key

ZMRUPTIKESYGQW-UQKRIMTDSA-N

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H/t14-;/m0./s1

SMILES string

Cl[H].CC(C)NC[C@H](O)COc1cccc2ccccc12

assay

≥98% (TLC)

form

powder

optical activity

[α]25/D −25.5°, c = 1.0 in ethanol(lit.)

mp

193-195 °C (lit.)

solubility

ethanol: 10 mg/mL, DMSO: <14.5 mg/mL, H2O: 50 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 8.0 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)

관련 카테고리

General description

With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.

Application

(S)-(−)-Propranolol hydrochloride has been used:
  • as a non-selective β-blocker propranolol to inhibit the actions of epinephrine in mice
  • as a β1- and β2-aadrenergic receptor blocker in rat
  • as a medium supplement to investigate its effect on adipogenesis in hemangioma-derived stem cells (HemSC)

Biochem/physiol Actions

(S)-(−)-Propranolol hydrochloride is biologically active enantiomer. It acts as β1 receptor antagonist in thalamocortical neurons. (S)-(−)-Propranolol hydrochloride elicits its inhibitory function on the β1 adrenoceptor in trigeminovascular pain pathway and serves as a preventive medicine in migraine.
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number

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