P9767
Sodium palmitate
≥98.5%
동의어(들):
Hexadecanoic acid sodium salt, Palmitic acid sodium salt
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CH3(CH2)14COONa
CAS 번호:
Molecular Weight:
278.41
UNSPSC Code:
12352211
NACRES:
NA.25
PubChem Substance ID:
EC Number:
206-988-1
Beilstein/REAXYS Number:
3575882
MDL number:
InChI key
GGXKEBACDBNFAF-UHFFFAOYSA-M
InChI
1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1
SMILES string
[Na+].CCCCCCCCCCCCCCCC([O-])=O
biological source
plant (palm)
assay
≥98.5%
form
powder
mp
283-290 °C (lit.)
functional group
ester
lipid type
saturated FAs
shipped in
ambient
storage temp.
2-8°C
Quality Level
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관련 카테고리
Application
Sodium palmitate (PA) has been used:
- to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay
- to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis
- as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining
Biochem/physiol Actions
Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps. Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis, cellular steatosis in various cell lines. Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation. Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Chemical composition of everyday products (2005)
Saturated free fatty acid sodium palmitate-induced lipoapoptosis by targeting glycogen synthase kinase-3 beta activation in human liver cells
Cao J, et al.
Digestive Diseases and Sciences, 59(2), 346-357 (2014)
Nicolas J Pillon et al.
Cell communication and signaling : CCS, 10(1), 30-30 (2012-10-20)
Obesity is associated with chronic low-grade inflammation. Within adipose tissue of mice fed a high fat diet, resident and infiltrating macrophages assume a pro-inflammatory phenotype characterized by the production of cytokines which in turn impact on the surrounding tissue. However
Hepatitis B virus X protein induces hepatic steatosis by enhancing the expression of liver fatty acid binding protein
Wu Y, et al.
Journal of Virology, 90(4), 1729-1740 (2016)
Linnéa Eriksson et al.
Cardiovascular diabetology, 11, 27-27 (2012-03-23)
The leading cause of death for patients suffering from diabetes is macrovascular disease. Endothelial dysfunction is often observed in type 2 diabetic patients and it is considered to be an important early event in the pathogenesis of atherogenesis and cardiovascular
문서
Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.
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