Q3625

Quinidine

Name: Quinidine
Brand: SIGMA

sodium channel blocker

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₀H₂₄N₂O₂

CAS 번호:

56-54-2

Molecular Weight:

324.42

NACRES:

NA.77

PubChem Substance ID:

24899331

UNSPSC Code:

12352200

EC Number:

200-279-0

MDL number:

MFCD00135581

Beilstein/REAXYS Number:

91866

주요 문서

모든 문서 보기

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제품 이름

Quinidine, anhydrous

InChI key

LOUPRKONTZGTKE-LHHVKLHASA-N

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1

SMILES string

COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1

grade

anhydrous

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

mp

168-172 °C (lit.)

originator

Bayer

Quality Level

200

Gene Information

human ... ABCB1(5243), CYP2D6(1565), CYP3A4(1576), KCNH1(3756), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

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Application

Quinidine has been used:

as an inhibitor of cytochrome P450 enzyme isoform CYP2D6
as a potassium (K⁺) channel blocker in microglia
to test its effect on electrophysiological behaviour of human induced pluripotent stem cells (hiPSC) cardiomyocytes

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

Quinidine, an isomer of quinine has potential side effects like proarrhythmia on usage. It prolongs cardiac potential and is sodium channel blocker. It is a potential antagonist for α1-adrenoceptors and contributes to hypotension. It inhibits cytochrome P450 2D6 and improves circulation and brain penetration of dementia drug, dextromethorphan. Quinidine-dextromethorphan combination may be useful in treating pseudobulbar affect (PBA).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS06

signalword

Danger

hcodes

H301,H317

pcodes

P261 - P264 - P272 - P280 - P301 + P310 - P302 + P352

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Action potential-based MEA platform for in vitro screening of drug-induced cardiotoxicity using human iPSCs and rat neonatal myocytes.

Danny Jans et al.

Journal of pharmacological and toxicological methods, 87, 48-52 (2017-05-28)

Drug-induced cardiotoxicity poses a negative impact on public health and drug development. Cardiac safety pharmacology issues urged for the preclinical assessment of drug-induced ventricular arrhythmia leading to the design of several in vitro electrophysiological screening assays. In general, patch clamp

Pharmacological treatments for alleviating agitation in dementia: a systematic review and network meta-analysis

Kongpakwattana K, et al.

British Journal of Clinical Pharmacology, 84(7), 1445-1456 (2018)

Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity

Rajendran P, et al.

Investigational New Drugs, 26(1), 25-34 (2008)

Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors

Shibata K, et al.

Circulation, 97(13), 1227-1230 (1998)

Cardiac Sodium Channel Disorders An Issue of Cardiac Electrophysiology Clinics E-Book, 6(4) (2015)

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for ADME/Tox

프로토콜

LC/MS/MS Analysis of Interacting Cardiac Drugs Digoxin, Quinidine, Amiodarone and Verapamil on Titan™ C18

Quinidine

sodium channel blocker

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

grade

impurities

mp

originator

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

ppe

문서

시험 성적서(COA)

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