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Merck

R3375

Retinyl palmitate

Type IV, ~1,800,000 USP units/g, oil

동의어(들):

Vitamin A palmitate, all−trans−Retinol palmitate

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C36H60O2
CAS 번호:
79-81-2
Molecular Weight:
524.86
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
24899361
EC Number:
201-228-5
Beilstein/REAXYS Number:
1917366
MDL number:
MFCD00019414

주요 문서

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InChI key

VYGQUTWHTHXGQB-FFHKNEKCSA-N

InChI

1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+

SMILES string

CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1

biological source

synthetic (organic)

type

Type IV

assay

≥90% (HPLC)

form

oil

specific activity

~1,800,000 USP units/g

color

yellow to orange

mp

26 °C

storage temp.

2-8°C

Quality Level

100

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관련 카테고리

General description

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A, respectively. The retinoids comprise a cyclohexenyl ring with a 20-carbon with double bonds in cis and trans configuration. Retinyl palmitate is a major storage form of vitamin A. Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed. Retinoids also exist as retinyl esters such as retinyl propionate, retinyl acetate and retinyl palmitate.

Application

Retinyl palmitate has been used as:
  • a retinoid derivative to modulate expression of connexin Cx26 and Cx30 in the cochlea
  • a standard in high performance liquid chromatography(HPLC)
  • as a retinoid substrate in the isomerase assay of eyecup protein homogenates

Biochem/physiol Actions

Retinoids are ligands to nuclear receptors and have antioxidant functionality. Retinyl palmitate is widely used in pharmaceutical and cosmetic applications. In sunscreen, it protects from UVB-induced DNA damage and apoptosis. Retinyl palmitate is used to treat photoaging in skincare cosmetics. Retinyl palmitate is an effective chemopreventive agent to treat lung cancer. It also regulates various biological processes including cell differentiation and proliferation.
Review: Vitamin A metabolism.

Packaging

Sealed ampule.

Physical form

Oil at room temperature

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Repr. 1B

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
MKCN5382
MKBR6526V
SLBC9044V
059K1601V
059K1601

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리 방문

Retinoids in cosmeceuticals
Sorg O, et al.
Dermatologic Therapy, 19(5), 289-296 (2006)
Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1beta responses
Patel S, et al.
Immunology, 148(4), 352-362 (2016)
Effects of retinoid treatment on cochlear development, connexin expression and hearing thresholds in mice
Kim Y and Lin X
Journal of Otorhinolaryngology, Hearing and Balance Medicine settings, 1(1), 2-2 (2018)
Laboratory evaluation during high-dose vitamin A administration: a randomized study on lung cancer patients after surgical resection
Infante M, et al.
Journal of Cancer Research and Clinical Oncology, 117(2), 156-162 (1991)
Safety of retinyl palmitate in sunscreens: a critical analysis
Wang SQ, et al.
Journal of the American Academy of Dermatology, 63(5), 903-906 (2010)
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