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R7772

Roscovitine

Name: Roscovitine
Brand: SIGMA

synthetic (organic), ≥98% (TLC), cyclin-dependent kinases inhibitor, powder

동의어(들):

2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₉H₂₆N₆O

CAS 번호:

186692-46-6

Molecular Weight:

354.45

UNSPSC Code:

12352200

PubChem Substance ID:

24278682

NACRES:

NA.77

MDL number:

MFCD02266401

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

기술 서비스

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속성

제품 이름

Roscovitine, ≥98% (TLC)

biological source

synthetic (organic)

Quality Level

200

assay

≥98% (TLC)

form

powder

mp

106-107 °C

solubility

chloroform: 50 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1

InChI

1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1

InChI key

BTIHMVBBUGXLCJ-OAHLLOKOSA-N

Gene Information

human ... CDK1(983), CDK2(1017), CDK5(1020), CDK7(1022), CDK9(1025), CDKN1A(1026), CDKN1B(1027), CDKN1C(1028), CDKN2A(1029), CDKN2B(1030), CDKN2C(1031), CDKN2D(1032), CDKN3(1033)
mouse ... CDK1(12534)
rat ... CDK1(54237)

설명

Application

Roscovitine has been used:

an inhibitor of p34cdc2/cyclin B kinase to preculture porcine oocytes
as a supplement in TCM199 medium for in vitro prematuration of cumulus-oocyte complexes (COCs) of adult goats
in astrocyte conditioned media as an inhibitor of cyclin-dependent kinase 5 (CDK5)
as a CDK2 inhibitor in culture media to treat hESCs

Biochem/physiol Actions

Roscovitine is a purine derived inhibitor. It stimulates apoptosis in cancer cells. It has inhibitory action on mitogen activated protein kinase (MAPK) and M-phase promoting factor (MPF) kinase activity. Roscovitine is known to arrest meiosis and thus, prevent embryonic development.

Roscovitine is a potent, selective inhibitor of cyclin-dependent kinases.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold under license from CNRS

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저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

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문서

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

세포 주기 연구를 위한 생체 활성 저분자

증식하는 세포에서 세포 주기는 4단계로 구성됩니다. Gap 1(G1)은 유사분열과 세포 성장을 특징으로 하는 DNA 복제 사이의 기간입니다. DNA 복제는 합성(S)기에 일어나며, 세포 분열을 위한 성장 및 준비를 하는 Gap 2(G2)가 뒤따릅니다. 이 세 단계는 함께 세포주기의 간기 단계를 구성합니다. 간기 이후에 분열(M)기가 뒤따릅니다.