S0664
Monoclonal Anti-Syntaxin antibody produced in mouse
clone HPC-1, ascites fluid
동의어(들):
Anti-HPC-1, Anti-P35-1, Anti-STX1, Anti-SYN1A
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
HPC-1, monoclonal
Application:
ARR, ICC, WB
Citations:
106
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
HPC-1, monoclonal
mol wt
antigen 35 kDa
contains
15 mM sodium azide
species reactivity
rat, bovine, rabbit
technique(s)
immunocytochemistry: suitable using monolayer cultures of neonatal retina cells, microarray: suitable, western blot: 1:2,000 using crude preparation of synaptic vesicles from rat cerebral cortex
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Stx1a(116470)
관련 카테고리
General description
Monoclonal Anti-Syntaxin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Syntaxin (also cited as HPC-1 antigen), a 35 kDa molecule with carboxyl-terminal membrane anchor is a synaptic protein. Syntaxin 1 is a membrane protein. Neurons express syntaxin 1A.
Syntaxin is a 35kD synaptic protein capable of interacting with the synaptic vesicle protein synaptotagmin. It facilitates the docking and fusion of synaptic vesicles with the plasma membrane. Monoclonal anti-syntaxin antibody can be used to screen λ gt 11 library of rat hippocampus to isolate syntaxin cDNA clones. It can also be used in microarray and immunocytochemistry. Mouse anti-syntaxin antibody reacts specifically with membrane protein syntaxin (35 kD). The product has also shown cross reactivity for rabbit, rat and bovine but not for guinea pig.
Immunogen
synaptosomal plasma-membrane fraction from adult rat hippocampus.
Application
Monoclonal Anti-Syntaxin antibody produced in mouse has been used in:
- immunoblotting
- immunohistochemistry
- immunoprecipitation from hippocampal lysate
- immunohistochemical analysis
Monoclonal anti-syntaxin antibody can be used in immunoprecipitation and immunohistochemistry. It can also be used in western blotting. Further, this product can also be used to label monolayer cultures of neonatal retinal cells and frozen paraformaldehyde fixed tissue sections.
Biochem/physiol Actions
Syntaxin 1 (STX1A) may control exocytosis in synaptic vesicles. In retina, STX1A may help in the structural formation of the inner nuclear layer (INL) and outer plexiform layer (OPL). Deletion of STX1A in mice affects the functions of hypothalamic-pituitary-adrenal axis. It may participate in spinal nociceptive plasticity promoted by peripheral nerve injury. It has been implicated in docking at synaptic vesicles of presynaptic neurotransmitter release sites.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
W Liu et al.
Biophysical journal, 91(2), 744-758 (2006-05-02)
Exocytotic release of neurotransmitters is mediated by the ternary soluble N-ethyl maleimide-sensitive fusion protein attachment protein receptors (SNAREs) complex, comprised of syntaxin (Sx), synaptosome-associated protein of 25 kDa (SNAP25), and synaptobrevin 2 (Sb2). Since exocytosis involves the nonequilibrium process of
M Tagaya et al.
The Journal of biological chemistry, 270(27), 15930-15933 (1995-07-07)
Syntaxin 1 (HPC-1), a component of the receptor for SNAPs (soluble N-ethylmaleimide-sensitive factor attachment proteins), has been implicated in the docking and fusion of synaptic vesicles with the plasma membrane. It was reported that syntaxin 1 in rat brain and
The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha-and beta-SNAPs
Osten P, et al.
Neuron, 21(1), 99-110 (1998)
Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter
Hara A, et al.
Stem Cells and Development, 17(4), 619-627 (2008)
Masataka Kunii et al.
The Journal of cell biology, 215(1), 121-138 (2016-10-05)
The membrane fusion of secretory granules with plasma membranes is crucial for the exocytosis of hormones and enzymes. Secretion disorders can cause various diseases such as diabetes or pancreatitis. Synaptosomal-associated protein 23 (SNAP23), a soluble N-ethyl-maleimide sensitive fusion protein attachment
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.