S0758
Sulfaphenazole
≥98%, CYP2C9 inhibitor, powder
동의어(들):
4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H14N4O2S
CAS 번호:
Molecular Weight:
314.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
208-384-3
MDL number:
제품 이름
Sulfaphenazole, ≥98%
InChI
1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
InChI key
QWCJHSGMANYXCW-UHFFFAOYSA-N
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3
assay
≥98%
form
powder
solubility
ethanol: 25 mg/mL, clear, colorless to yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... CYP2C18(1562), CYP2C19(1557), CYP2C9(1559)
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Application
Sulfaphenazole has been used as a positive control to inhibit cytochrome P450 2C9 (cyp2c9) to quantify Rhodiola rosea inhibition. It has also been used as cytochrome P450 2C9 (cyp2c9) inhibitor in endothelial cells and microsomal preparations.
Biochem/physiol Actions
Antibacterial. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Specific inhibitor of CYP2C9. Blocks pro-inflammatory and atherogenic effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. Inhibits bradykinin-induced tPA release.
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Noncompetitive inhibition of human CYP 2C9 in vitro by a commercial Rhodiola rosea product
Thu OKF, et al.
Pharmacology Research & Perspectives, 5(4), e00324-e00324 (2017)
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
Moraes CB, et al.
SLAS discovery, 24(3), 346-361 (2019)
Simon Lucas et al.
Journal of medicinal chemistry, 51(24), 8077-8087 (2008-12-04)
Pyridine substituted naphthalenes (e.g., I-III) constitute a class of potent inhibitors of aldosterone synthase (CYP11B2). To overcome the unwanted inhibition of the hepatic enzyme CYP1A2, we aimed at reducing the number of aromatic carbons of these molecules because aromaticity has
Simon Lucas et al.
Journal of medicinal chemistry, 51(19), 6138-6149 (2008-09-04)
Pharmacophore modeling of a series of aldosterone synthase (CYP11B2) inhibitors triggered the design of compounds 11 and 12 by extending a previously established naphthalene molecular scaffold (e.g., present in molecules 1 and 2) via introduction of a phenyl or benzyl
Chengqun Huang et al.
American journal of physiology. Heart and circulatory physiology, 298(2), H570-H579 (2009-12-17)
Previously, we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against ischemia-reperfusion (I/R) injury (Ref. 15). The mechanism, however, underlying this cardioprotection, is largely unknown. With evidence that activation of autophagy
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