S193

Anti-Synapsin I antibody produced in rabbit

Name: Anti-Synapsin I antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, lyophilized powder

동의어(들):

Anti-EPILX, Anti-MRX50, Anti-SYN1a, Anti-SYN1b, Anti-SYNI

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00282157

Conjugate:

unconjugated

Clone:

polyclonal

Application:

DB, IF, IHC (f), IP, WB

Citations:

주요 문서

모든 문서 보기

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도움 문의

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도움 문의

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

mol wt

antigen ~80 kDa (Synapsin Ia)

species reactivity

rat, mouse, human, bovine

technique(s)

dot blot: 1:1000, immunohistochemistry (frozen sections): 1:2000, immunoprecipitation (IP): 1 μg, indirect immunofluorescence: 1:2000, western blot: 1:1000

UniProt accession no.

P17600

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SYN1(6853)
mouse ... Syn1(20964)
rat ... Syn1(24949)

General description

Synapsin I (1a and 1b) refers to two nearly identical phosphoproteins found in the cytoplasmic surface of synaptic vesicles of the CNS (central nervous system) and PNS(peripheral nervous system). It may be used to localize and detect synapsin I (synapsins Ia and Ib are collectively referred to as synapsin I) in nerve terminals.The SYN1 gene is mapped to human chromosome Xp11.3-p11.23.

Immunogen

synapsin I from bovine brain.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.

Western Blotting (1 paper)
immunohistochemistry
immunoblotting
immunoprecipitation
ELISA.

Rabbit polyclonal anti-Synapsin I antibody can be used for the localization and detection of synapsin I (synapsins Ia and Ib, approximately 80 kDa and 77 kDa, are collectively referred to as synapsin I) in nerve terminals.

Biochem/physiol Actions

Synapsin I is involved in the regulation of axonogenesis and synaptogenesis wherein it serves as a substrate of various protein kinases including those activated by cAMP, calciuim/calmodulin, mitogens, and cyclins. The antibody strongly reacts with the synapsin I doublet. Synapsin I is associated with vesicle trafficking. Mutation in this gene is one of the known cause for familial epilepsy and autism spectrum disorders.

Physical form

Lyophilized from ammonium bicarbonate (5 mM)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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저장 등급

13 - Non Combustible Solids

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 문서 section.

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Nonsense-mediated mRNA decay and loss-of-function of the protein underlie the X-linked epilepsy associated with the W356? mutation in synapsin I.

Giannandrea M, et al.

PLoS ONE, 8(6), e67724-e67724 (2013)

Synapsin III: role in neuronal plasticity and disease.

Porton B, et al.

Seminars in Cell & Developmental Biology, 22(4), 416-424 (2011)

Increased synapsin I expression in cerebral malaria.

Thonsranoi K, et al.

International Journal of Clinical and Experimental Pathology, 8(11), 13996-13996 (2015)

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections.

P De Camilli et al.

The Journal of cell biology, 96(5), 1337-1354 (1983-05-01)

Synapsin I (formerly referred to as protein I) is the collective name for two almost identical phosphoproteins, synapsin Ia and synapsin Ib (protein Ia and protein Ib), present in the nervous system. Synapsin I has previously been shown by immunoperoxidase

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

Huttner W B, et al.

The Journal of Cell Biology, 96(5), 1374-1388 (1983)

모든 관련된 서류 보기

Anti-Synapsin I antibody produced in rabbit

affinity isolated antibody, lyophilized powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

technique(s)

UniProt accession no.

storage temp.

target post-translational modification

Quality Level

Gene Information

관련 카테고리

설명

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

Disclaimer

안전성 정보

저장 등급

wgk

ppe

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

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