S4322
Anti-Sirt6 (N-terminal) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
동의어(들):
Anti-NAD-dependent deacetylase sirtuin 6, Anti-SIR2-like protein 6, Anti-SIR2L6
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
19
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~40 kDa
species reactivity
rat (predicted), mouse, human
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
western blot: 2-4 μg/mL using whole extracts of human 293 cells transfected with Sirt6, western blot: 2-4 μg/mL using whole extracts of mouse 3T3 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SIRT6(51548)
rat ... Sirt6(299638)
General description
Sirtuin 6 (Sirt6) is a nuclear and chromatin-associated protein that belongs to the mammalian Sir2 gene family. It is broadly expressed with the highest levels in muscle, brain and heart.
Immunogen
synthetic peptide corresponding to amino acids 19-33 of human Sirt6 via a C-terminal cysteine residue. The sequence is identical in mouse and differs by one amino acid in rat.
Application
Anti-Sirt6 (N-terminal) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Anti-Sirt6 (N-terminal) recognizes human and mouse Sirt6. The detection of the Sirt6 band by immunoblotting is specifically inhibited with the immunizing peptide.
Sirtuin 6 (Sirt6) plays a key role in DNA repair and maintenance of genomic stability in cells. Sirt6 is enzymatically inactive as a NAD+ -dependent protein deacetylase but displays auto-ADP-ribosyltransferase activity. Loss of Sirt6 leads to the development of an acute degenerative aging-like phenotype.
Physical form
Solution in 0.01 M phosphate buffered, saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
Liszt G, et al.
The Journal of Biological Chemistry, 280 (2005)
Sergii Domanskyi et al.
Apoptosis : an international journal on programmed cell death, 22(11), 1336-1343 (2017-09-01)
Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we
Differential expression of sirtuin family members in the developing, adult, and aged rat brain
Sidorova-Darmos E, et al.
Frontiers in Aging Neuroscience, 6 (2014)
Justin W Nicholatos et al.
Acta neuropathologica communications, 6(1), 120-120 (2018-11-10)
Parkinson's disease is characterized by progressive death of dopaminergic neurons, leading to motor and cognitive dysfunction. Epidemiological studies consistently show that the use of tobacco reduces the risk of Parkinson's. We report that nicotine reduces the abundance of SIRT6 in
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky R, et al.
Cell, 124 (2006)
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