S4572
SANT-1
≥98% (HPLC), powder, SHH antagonist
동의어(들):
(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C23H27N5
CAS 번호:
Molecular Weight:
373.49
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
SANT-1, ≥98% (HPLC), powder
SMILES string
Cc1nn(-c2ccccc2)c(C)c1\C=N\N3CCN(CC3)Cc4ccccc4
InChI
1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
InChI key
FOORCIAZMIWALX-JJIBRWJFSA-N
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
Quality Level
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관련 카테고리
Application
- SANT-1 has been used: to treat cells and study the effect of SANT1-mediated inhibition on hedgehog signaling
- in the generation of functional human pancreatic β cells in vitro
- to treat of Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma cells2 and chronic lymphocytic leukemia cells3 with SANT-1 induced cell death
Biochem/physiol Actions
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist that directly inhibits by binding to the smoothened (Smo) receptor. SANT-1 inhibits wild type and oncogenic Smo with equal potency.
SANT-1 is a potent sonic hedgehog pathway (Shh) antagonist.
SANT-1 is known to induce apoptosis via Ras/NF-κB pathway in glioblastoma cells.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Deobrat Dixit et al.
Cancer letters, 336(2), 347-358 (2013-04-04)
Since Shh pathway effector, Gli1, is overexpressed in gliomas, we investigated the effect of novel Shh inhibitor SANT-1 on glioma cell viability. Though SANT-1 failed to induce apoptosis, it reduced proliferation of glioma stem-like cells. Apart from canonical Shh cascade
P Desch et al.
Oncogene, 29(35), 4885-4895 (2010-07-07)
The Hedgehog (Hh) pathway regulates cell proliferation and survival and contributes to tumorigenesis. We investigated the expression and function of this pathway in B-cell chronic lymphocytic leukemia (CLL) cells and in healthy B lymphocytes. Profiling of cognate Hh pathway members
Rajesh R Singh et al.
Cancer research, 69(6), 2550-2558 (2009-02-27)
Deregulation of the sonic hedgehog (SHH) signaling pathway has been implicated in several cancers but has not been explored in T-cell lymphomas. Here, we report that the SHH/GLI1 signaling pathway is activated in anaplastic lymphoma kinase (ALK)-positive anaplastic large cell
Sigrid Nachtergaele et al.
eLife, 2, e01340-e01340 (2013-10-31)
The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate
Feorillo Galivo et al.
PloS one, 12(8), e0181812-e0181812 (2017-08-17)
The gallbladder and cystic duct (GBCs) are parts of the extrahepatic biliary tree and share a common developmental origin with the ventral pancreas. Here, we report on the very first genetic reprogramming of patient-derived human GBCs to β-like cells for
문서
Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.
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