S6942
Staurosporine solution from Streptomyces sp.
Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
동의어(들):
Antibiotic AM-2282
제품 이름
Staurosporine solution from Streptomyces sp., Ready Made Solution, 1 mM in DMSO (100 μg/214 μL)
assay
>98% (HPLC)
concentration
1 mM in DMSO (100 μg/214 μL)
technique(s)
cell culture | mammalian: suitable
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Chemical structure: indol derivative
Application
Staurosporine solution from Streptomyces sp. was used to study the effect of PKC inhibition on signaling mediated by angiotensin II.3 It was used to induce cell death in Jurkat cells.4
Biochem/physiol Actions
Potent cell-permeable inhibitor of protein kinase C. Induces apoptosis in Jurkat cells.
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
저장 등급
10 - Combustible liquids
flash_point_f
188.6 °F - closed cup
flash_point_c
87 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Maren de Vries et al.
bioRxiv : the preprint server for biology (2020-09-02)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of Coronavirus Disease 2019 (COVID-19). There is a dire need for novel effective antivirals to treat COVID-19, as the only approved direct-acting antiviral to date is remdesivir, targeting the
Yu-Jung Lee et al.
American journal of physiology. Renal physiology, 292(1), F340-F350 (2006-08-10)
Vasopressin and angiotensin II (ANG II) play a major role in renal water and Na(+) reabsorption. We previously demonstrated that ANG II AT(1) receptor blockade decreases dDAVP-induced water reabsorption and AQP2 levels in rats, suggesting cross talk between these two
G Warnes et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 79(3), 181-191 (2011-01-22)
The standard method of distinguishing apoptotic and oncotic cells has been by microscopic analysis of nuclei and cell membrane morphology. Thus a rapid test for analyzing large numbers of cells in the study of cell necrobiology has not been possible
S Lauren Kyte et al.
The Journal of pharmacology and experimental therapeutics, 364(1), 110-119 (2017-10-19)
Chemotherapy-induced peripheral neuropathy (CIPN), a consequence of peripheral nerve fiber dysfunction or degeneration, continues to be a dose-limiting and debilitating side effect during and/or after cancer chemotherapy. Paclitaxel, a taxane commonly used to treat breast, lung, and ovarian cancers, causes
Selma Tuzlak et al.
The FEBS journal, 285(8), 1403-1418 (2018-03-03)
Overexpression of BCLX and BFL1/A1 has been reported in various human malignancies and is associated with poor prognosis and drug resistance, identifying these prosurvival BCL2 family members as putative drug targets. We have generated transgenic mice that express human BFL1
문서
Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
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