콘텐츠로 건너뛰기
Merck

SAB4200585

Anti-ERGIC-53 antibody, Mouse monoclonal

clone ERGIC-3, purified from hybridoma cell culture

동의어(들):

Monoclonal Anti-ER-Golgi intermediate compartment 53 kDa protein, Monoclonal Anti-ERGIC-53 antibody produced in mouse, Monoclonal Anti-ERGIC53, Monoclonal Anti-F5F8D, Monoclonal Anti-Gp58, Monoclonal Anti-Intracellular mannose-specific lectin MR60, Monoclonal Anti-LMAN1, Monoclonal Anti-Lectin mannose-binding 1

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
ERGIC-3, monoclonal
Application:
—
Citations:
5

주요 문서

모든 문서 보기
기술 서비스
도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.
도움 문의
기술 서비스
도움이 필요하신가요? 저희 숙련된 과학자 팀이 도와드리겠습니다.
도움 문의

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

ERGIC-3, monoclonal

form

buffered aqueous solution

mol wt

antigen ~58 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

immunoblotting: 1-2 μg/mL using whole extracts of human HeLa cells.

isotype

IgG1

UniProt accession no.

P49257

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... LMAN1(3998)
mouse ... Lman1(70361)
rat ... Lman1(116666)

General description

Endoplasmic reticulum-Golgi intermediate compartment 53kDa protein (ERGIC-53), a nonglycosylated, hexameric type I integral membrane protein is also known as LMAN1 (lectin, mannose-binding 1). This gene is located on human chromosome 18q21.32.

Immunogen

synthetic peptide corresponding to an internal sequence of human ERGIC-53, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine and monkey.

Biochem/physiol Actions

Endoplasmic reticulum-Golgi intermediate compartment protein 53kDa protein (ERGIC-53) plays an important role in the proliferation of arenavirus, coronavirus and filovirus. This intracellular cargo receptor enables the anterograde passage of very few glycoprotein ligands in the early exocytic pathway. Mutations in ERGIC-53 (LMAN1) gene results in the deficiency of factor V and factor VIII.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

적합한 제품을 찾을 수 없으신가요?  

당사의 제품 선택기 도구.을(를) 시도해 보세요.

저장 등급

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
059M4800V
059M4800
22180617
033N4756V
033M4756V

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP+
Brill L B II, et al.
Experimental Neurology, 181(1), 25-38 (2003)
Two new mutations at ERGIC-53 gene in a Turkish family
Torun, et al.
Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(3), 248-250 (2011)
The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles
Klaus JP, et al.
Cell host & microbe, 14(5), 522-534 (2013)
Mariana L Ferrari et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(27), 13582-13591 (2019-06-19)
Intracellular trafficking pathways in eukaryotic cells are essential to maintain organelle identity and structure, and to regulate cell communication with its environment. Shigella flexneri invades and subverts the human colonic epithelium by the injection of virulence factors through a type
Xiang Gui et al.
Nature, 567(7747), 262-266 (2019-03-08)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm1. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK

관련 콘텐츠

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.