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SML0313

Pimelic Diphenylamide 106

≥98% (HPLC)

동의어(들):

Compound 106, Inhibitor 106, N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide, RGFA 8, TC-H 106

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C20H25N3O2
CAS 번호:
937039-45-7
Molecular Weight:
339.43
NACRES:
NA.77
PubChem Substance ID:
329825318
UNSPSC Code:
12352200
MDL number:
MFCD17010287
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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도움 문의

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥15 mg/mL

storage temp.

2-8°C

SMILES string

Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1

InChI

1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)

InChI key

WTKBRPXPNAKVEQ-UHFFFAOYSA-N

관련 카테고리

Biochem/physiol Actions

106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.
106 is a potent Class I HDAC inhibitor, demonstrating no activity against class II HDACs.
Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases
Chou CJ, et al.
The Journal of Biological Chemistry, 283(51), 35402-35409 (2008)
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PLoS pathogens, 17(2), e1009307-e1009307 (2021-02-18)
Marek's disease virus (MDV) is a potent oncogenic alphaherpesvirus that elicits a rapid onset of malignant T-cell lymphomas in chickens. Three MDV types, including GaHV-2 (MDV-1), GaHV-3 (MDV-2) and MeHV-1 (HVT), have been identified and all encode a US3 protein
Jason A Pfister et al.
PloS one, 14(4), e0215208-e0215208 (2019-04-12)
SIRT1, a NAD+-dependent deacetylase, protects neurons in a variety of in vitro and in vivo models of neurodegenerative disease. We have previously described a neuroprotective effect by SIRT1 independent of its catalytic activity. To confirm this conclusion we tested a
Dominik Stammler et al.
Journal of immunology (Baltimore, Md. : 1950), 195(11), 5421-5431 (2015-11-01)
Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the surprising finding that HDACi promote LPS-induced IL-1β processing and secretion in human and murine dendritic cells and murine macrophages. HDACi/LPS-induced IL-1β maturation
Angela K Carrillo et al.
Bioorganic & medicinal chemistry, 23(16), 5151-5155 (2015-02-01)
Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDACi) for their ability to block proliferation of Trypanosoma brucei

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