SML1072

GSK-LSD1

Name: GSK-LSD1
Brand: SIGMA

≥98% (HPLC), lysine specific demethylase 1 (LSD1) inhibitor, powder

동의어(들):

GSK-LSD1 (trans-racemic) dihydrochloride, rel- N-[(1R,2S)-2-Phenylcyclopropyl]-4-Piperidinamine hydrochloride (1:2)

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₄H₂₀N₂ · 2HCl

CAS 번호:

1431368-48-7

Molecular Weight:

289.24

UNSPSC Code:

51111800

PubChem Substance ID:

329825454

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

주요 문서

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제품 이름

GSK-LSD1, ≥98% (HPLC)

SMILES string

C1(N[C@@H]2C[C@H]2C3=CC=CC=C3)CCNCC1

InChI

1S/C14H20N2/c1-2-4-11(5-3-1)13-10-14(13)16-12-6-8-15-9-7-12/h1-5,12-16H,6-10H2/t13-,14+/m0/s1

InChI key

BASFYRLYJAZPPL-UONOGXRCSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Application

GSK-LSD1 has been used as a lysine specific demethylase 1 (LSD1) inhibitor in mice to study sepsis-induced mortality. It has also been used as an inhibitor to study if the effect of phenelzine activation of human immunodeficiency virus (HIV) latency is caused due to LSD1.

Biochem/physiol Actions

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1 (LSD1). GSK-LSD1 potently inhibits proliferation of varies cancer cell lines by changing gene expression patterns. For full characterization details, please visit the GSK-LSD1 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

GSK-LSD1 is a potent and selective inhibitor of lysine specific demethylase 1.

Features and Benefits

GSK-LSD1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy.

Antonio Romo-Morales et al.

Pediatric blood & cancer, 66(9), e27888-e27888 (2019-06-18)

Ewing sarcoma and desmoplastic small round cell tumors (DSRCT) are rare and clinically aggressive sarcomas usually characterized by oncogenic fusion proteins involving EWS. Emerging studies of Ewing sarcoma have demonstrated EWS-FLI1-driven chromatin remodeling as a key aspect of tumorigenicity. In

HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency

Llewellyn GN, et al.

Journal of Neurovirology, 1-12 (2017)

PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

Kim D, et al.

Molecular Cell, 69(3), 398-411 (2018)

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.

Kimberly N Smitheman et al.

Haematologica, 104(6), 1156-1167 (2018-12-06)

Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD1, has previously been described. Inhibition

Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis.

Isuru R Kumarasinghe et al.

European journal of medicinal chemistry, 148, 210-220 (2018-02-21)

Lysine-specific demethylase 1 (LSD1) is a chromatin-remodeling enzyme that plays an important role in cancer. Over-expression of LSD1 decreases methylation at histone 3 lysine 4, and aberrantly silences tumor suppressor genes. Inhibitors of LSD1 have been designed as chemical probes

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문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

GSK-LSD1

≥98% (HPLC), lysine specific demethylase 1 (LSD1) inhibitor, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI

InChI key

assay

form

color

solubility

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

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