SML1482
Ogerin
≥98% (HPLC)
동의어(들):
2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-benzenemethanol, [2-[4-Amino-6-(benzylamino)-1,3,5-triazin-2-yl]phenyl]methanol
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C17H17N5O
CAS 번호:
Molecular Weight:
307.35
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
SMILES string
OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1
InChI
1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22)
InChI key
MDGIEDNDSFMSLP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
2-8°C
Quality Level
Application
Ogerin has been used in G-protein-coupled receptors (GPCR) deorphanization and phosphatidylinositol hydrolysis assay.
Biochem/physiol Actions
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1).
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.
Other Notes
Ogerin negative control, a structurally similar analog of ogerin, is available from Sigma. To learn more about and purchase ogerin negative control, click here.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Discovery of new GPCR ligands to illuminate new biology
Roth B L, et al.
Nature chemical biology, 13(11), 1143-1143 (2017)
Xi-Ping Huang et al.
Nature, 527(7579), 477-483 (2015-11-10)
At least 120 non-olfactory G-protein-coupled receptors in the human genome are 'orphans' for which endogenous ligands are unknown, and many have no selective ligands, hindering the determination of their biological functions and clinical relevance. Among these is GPR68, a proton
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