T2780
Monoclonal Anti-Tropomyosin antibody produced in mouse
clone TM311, ascites fluid
동의어(들):
Anti-Tropomyosin Antibody
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
TM311, monoclonal
Application:
ARR, ELISA (i), IF, IP, WB
Citations:
50
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
TM311, monoclonal
mol wt
antigen 36-39 kDa
contains
15 mM sodium azide
species reactivity
pig, chicken, bovine, rabbit, mouse, hamster, rat, human
technique(s)
immunoprecipitation (IP): suitable, indirect ELISA: suitable, indirect immunofluorescence: 1:400 using chicken fibroblasts, microarray: suitable, western blot: suitable using human tissue and chicken gizzard extracts
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
bovine ... TPM1(281544)
chicken ... TPM1(396366)
human ... TPM1(7168)
mouse ... Tpm1(22003)
rat ... Tpm1(24851)
General description
Monoclonal Anti-Tropomyosin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Tropomyosin is a rigid rod-shaped protein closely associated with actin filaments. Non-muscle forms of tropomyosin have been identified in a wide range of cell types. Tropomyosin is made of two α helical polypeptide chains.
Immunogen
chicken gizzard tropomyosin.
Application
Monoclonal Anti-Tropomyosin has been used:
- in immunofluorescent labelling
- in immunohistochemistry
- in western blotting
- in immunoblotting
Mouse monoclonal clone TM311 anti-Tropomyosin antibody is used to tag tropomyosin for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. It is used as a probe to determine the presence and roles of tropomyosin in cytoskeletal structures.
Biochem/physiol Actions
Tropomyosin together with troponin, regulate the binding of myosin to actin. Tropomyosin is a dimeric coiled-coil protein forming continuous polymers along the myosin-binding groove of actin. Various tropomyosin isoforms help to confer structure and function to actins in the cytoskeleton and in striated muscle function.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Activation of MAP kinases and phosphorylation of caldesmon in canine colonic smooth muscle.
Gerthoffer W T, et al.
The Journal of Physiology, 495(3), 597-609 (1996)
Iman Jalilian et al.
PloS one, 10(5), e0126214-e0126214 (2015-05-16)
The actin cytoskeleton is the primary polymer system within cells responsible for regulating cellular stiffness. While various actin binding proteins regulate the organization and dynamics of the actin cytoskeleton, the proteins responsible for regulating the mechanical properties of cells are
Non-canonical Wnt signaling enhances differentiation of Sca1+/c-kit+ adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes
Palpant N J, et al.
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