T2879
Tyramine hydrochloride
≥98% (TLC), powder, neuromodulator
동의어(들):
4-(2-Aminoethyl)phenol hydrochloride, 4-Hydroxyphenethylamine hydrochloride, Tyrosamine hydrochloride
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
HOC6H4CH2CH2NH2 · HCl
CAS 번호:
Molecular Weight:
173.64
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
200-462-5
MDL number:
Beilstein/REAXYS Number:
3627058
제품 이름
Tyramine hydrochloride, ≥98%
InChI
1S/C8H11NO.ClH/c9-6-5-7-1-3-8(10)4-2-7;/h1-4,10H,5-6,9H2;1H
InChI key
RNISDHSYKZAWOK-UHFFFAOYSA-N
SMILES string
Cl[H].NCCc1ccc(O)cc1
assay
≥98%
mp
271-274 °C (lit.)
solubility
H2O: soluble 50 mg/ml, clear, colorless to faintly yellow
Quality Level
Gene Information
human ... ADORA2A(135), ADORA2B(136), ADORA3(140)
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Application
Tyramine hydrochloride has been:
- coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure
- labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis
- used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification
Biochem/physiol Actions
Can enter catecholaminergic terminals and be released as a false transmitter.
Tyramine is a biogenic amine and a neuromodulator localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders. Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Immunostaining Enhancement
Immunohistochemistry: Basics and Methods, 47-59 (2009)
Two functional but noncomplementing Drosophila tyrosine decarboxylase genes distinct roles for neural tyramine and octopamine in female fertility
Cole Shannon H, et al.
Test, 280(15), 14948-14955 (2005)
Urocortin and corticotropin-releasing factor receptor 2 in human renal cell carcinoma: disruption of an endogenous inhibitor of angiogenesis and proliferation
Tezval Hossein, et al.
World Journal of Urology, 27(6), 825-825 (2009)
A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster
Nagaya Y, et al.
Neuroscience Letters, 329(3), 324-328 (2002)
Pia Thaning et al.
Diabetes care, 34(5), 1186-1191 (2011-03-31)
Sympathetic vasoconstriction is blunted in contracting human skeletal muscles (functional sympatholysis). In young subjects, infusion of adenosine and ATP increases blood flow, and the latter compound also attenuates α-adrenergic vasoconstriction. In patients with type 2 diabetes and age-matched healthy subjects
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