T9531
D-(+)-Trehalose dihydrate
≥99% (HPLC), from Saccharomyces cerevisiae
동의어(들):
Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H22O11 · 2H2O
CAS 번호:
Molecular Weight:
378.33
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
EC Number:
202-739-6
Beilstein/REAXYS Number:
5322018
MDL number:
InChI key
DPVHGFAJLZWDOC-PVXXTIHASA-N
InChI
1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
SMILES string
[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
biological source
Saccharomyces cerevisiae
assay
≥99% (HPLC)
form
powder
optical activity
[α]20/D 174 to 182 °, c = 7% (w/v) in water
technique(s)
HPLC: suitable, PCR: suitable, cell based assay: suitable, cryopreservation: suitable
impurities
≤5.0% EtOH, <20 ppm Trace metals
color
white
mp
97-99 °C
solubility
water: 50 mg/mL, clear, colorless
application(s)
advanced drug delivery
agriculture
cell analysis
life science and biopharma
sample preparation
storage temp.
room temp
Quality Level
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General description
Trehalose, also known as mycose or tremalose, is a nonreducing disaccharide of glucose commonly found in fungi, bacteria, and invertebrates. Its presence in these organisms highlights its significance in various biological processes and potential applications in biochemical research and cell culture studies.
Application
D-(+)-Trehalose dihydrate has been used:
- as a transcription factor EB (TFEB) to study its effects on an autophagy-lysosomal system in human silicosis alveolar macrophages
- as stabilizing excipient in spray-dried protein formulations
- as a cryoprotectant to study its effects on mouse testicular cell suspensions
Biochem/physiol Actions
D-(+)-Trehalose shows anti-desiccant and cryopreservative activities. It acts as an osmolyte, and stress protectant and helps in the storage and transport of carbon. Trehalose is involved in the food, cosmetic, and pharmaceutical industries. It plays a vital role in the survival of certain insects and plants known as anhydrobionts during harsh environments such as high rates of dehydration.
Preparation Note
Prepared by ion exchange chromatography.
Analysis Note
Reduced metal ion content.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Alan Twomey et al.
International journal of pharmaceutics, 487(1-2), 91-100 (2015-04-19)
In frozen and lyophilized systems, the biological to be stabilized (e.g. therapeutic protein, biomarker, drug-delivery vesicle) and the cryo-/lyo-protectant should be co-localized for successful stabilization. During freezing and drying, many factors cause physical separation of the biological from the cryo-/lyo-protectant
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