U4375

Uridine 5′-diphospho-N-acetylglucosamine sodium salt

Name: Uridine 5&#8242;-diphospho-N-acetylglucosamine sodium salt
Brand: SIGMA

≥98%, from bakers yeast, powder

동의어(들):

UDP-GlcNAc, UDP-N-acetylglucosamine, UDPAG

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

C₁₇H₂₅N₃O₁₇P₂Na₂

CAS 번호:

91183-98-1

Molecular Weight:

651.32

NACRES:

NA.51

PubChem Substance ID:

24900646

UNSPSC Code:

41106305

EC Number:

293-820-5

MDL number:

MFCD00799985

Assay:

≥98%

Biological source:

bakers yeast

Form:

powder

Solubility:

water: 50 mg/mL, clear to hazy, colorless

Storage temp.:

−20°C

주요 문서

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제품 이름

Uridine 5′-diphospho-N-acetylglucosamine sodium salt, ≥98%

biological source

bakers yeast

Quality Level

200

assay

≥98%

form

powder

solubility

water: 50 mg/mL, clear to hazy, colorless

storage temp.

−20°C

SMILES string

[Na+].[Na+].CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C17H27N3O17P2.2Na/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28;;/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28);;/q;2*+1/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-;;/m1../s1

InChI key

HXWKMJZFIJNGES-YZVFIFBQSA-L

General description

Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a nucleotide sugar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). UDP-GlcNAc is transported actively into Golgi, nucleotide sugar transporter (NST). The levels of UDP-GlcNAc is modulated by the concentration of nutrients exposed to the cell.

Application

Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) sodium salt has been used:

as a component of reaction cocktail in endoplasmic reticulum to Golgi transport assay
as a reference standard for the quantification of UDP-GlcNAc in liver tissues using high-performance liquid chromatography (HPLC)
in testing the glycosylation activity of O-GlcNAc transferase (OGT) against peptide substrate

Biochem/physiol Actions

Donor substrate for transfer of GlcNAc to the dolichol precursor in the synthesis of N-glycans. UDP-GlcNAc also functions as the source of GlcNAc attached to serine/threonine residues by O-GlcNAc transferase (OGT) in O-GlcNAc signaling.

Uridine 5′-diphospho-N-acetylglucosamine (UDP-GlcNAc) is a sugar donor and aids in the endomembrane glycosylation of endoplasmic reticulum and Golgi. The decreased levels of UDP-GlcNAc has an influence on the normal cellular proliferation and apoptosis. UDP-GlcNAc elicits feedback inhibition of the enzyme glutamine:fructose-6-phosphate amidotransferase (GFAT).

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Lot/Batch Number

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문서 라이브러리 방문

Systematic analysis of barrier-forming FG hydrogels from Xenopus nuclear pore complexes.

Aksana A Labokha et al.

The EMBO journal, 32(2), 204-218 (2012-12-04)

Nuclear pore complexes (NPCs) control the traffic between cell nucleus and cytoplasm. While facilitating translocation of nuclear transport receptors (NTRs) and NTR·cargo complexes, they suppress passive passage of macromolecules 30 kDa. Previously, we reconstituted the NPC barrier as hydrogels comprising S.

Protein

Stephanie M Halmo et al.

The Journal of biological chemistry, 292(6), 2101-2109 (2016-12-10)

Disruption of the

Enhanced transfer of a photocross-linking N-acetylglucosamine (GlcNAc) analog by an O-GlcNAc transferase mutant with converted substrate specificity

Rodriguez AC, et al.

The Journal of biological chemistry, 290(37), 22638-22648 (2015)

Structure and Function of N-Acetylmannosamine Kinases from Pathogenic Bacteria.

Thanuja Gangi Setty et al.

ACS omega, 5(48), 30923-30936 (2020-12-17)

Several pathogenic bacteria import and catabolize sialic acids as a source of carbon and nitrogen. Within the sialic acid catabolic pathway, the enzyme N-acetylmannosamine kinase (NanK) catalyzes the phosphorylation of N-acetylmannosamine to N-acetylmannosamine-6-phosphate. This kinase belongs to the ROK superfamily

A Golgi UDP-GlcNAc transporter delivers substrates for N-linked glycans and sphingolipids

Ebert B, et al.

Nature plants, 1-1 (2018)

모든 관련된 서류 보기

문서

Analysis: Activated Nucleotide Sugars by LC-MS/MS

LC-MS/MS method quantifies similar polar nucleotide activated sugars using Supel™ Carbon LC column for simultaneous analysis.

Glycosyltransferases

Enzymatic glycosyltransferase specificity challenges the one enzyme-one linkage concept.

Glycosyltransferases: Tools for Synthesis and Modification of Glycans

Explore tools for glycosyltransferase synthesis and modification of glycans, such as glycosyltransferases and nucleotide sugar donors.

Sialic Acid

Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.

Uridine 5′-diphospho-N-acetylglucosamine sodium salt

≥98%, from bakers yeast, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

biological source

Quality Level

assay

form

solubility

storage temp.

SMILES string

InChI

InChI key

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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