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Merck

F7878

Folinic acid calcium salt hydrate

analytical standard

Sinónimos:

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

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Fórmula empírica (notación de Hill):
C20H21CaN7O7 · xH2O
Número CAS:
1492-18-8
Peso molecular:
511.50 (anhydrous basis)
MDL number:
MFCD00149463
UNSPSC Code:
41116107
PubChem Substance ID:
24894951
NACRES:
NA.24
Beilstein/REAXYS Number:
5723924

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Nombre del producto

Folinic acid calcium salt hydrate, analytical standard

SMILES string

[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

InChI key

KVUAALJSMIVURS-ZEDZUCNESA-L

biological source

synthetic (organic)

grade

analytical standard

assay

≥90.0%

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

yellow to orange

mp

240-250 °C

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

Quality Level

100

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Application

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique.
Folinic acid calcium salt hydrate has been used as a test compound to study its effects on microglia involved in neuro-inflammation using enzyme-linked immunosorbent assay (ELISA) technique. Folinic acid calcium salt hydrate may be used as an analytical reagent for the quantification of methotrexate its metabolites in biological samples using turbulent flow chromatography with tandem mass spectrometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Folinic acid calcium salt hydrate is a drug, widely used for the treatment of cancer, since it can reduce toxic side effects and helps to improve drug accumulation in tumor tissues.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
WXBD5639V
WXBD4434V
WXBD2569V
WXBD1179V
WXBC9955V

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