918881
NanoFabTx™ PEG-PCL drug formulation screening kit
for synthesis of PEGylated nanoparticles
別名:
Drug delivery reagent kit, NanoFabTx reagent kit, Nanoparticle synthesis kit, PEG-PCL
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この商品について
NACRES:
NA.23
UNSPSC Code:
12161503
Storage temp.:
2-8°C
Quality Level
description
Drug loading screening kit, for synthesis of PEGylated PCL nanoparticles, Kit components :
PEGPCL-L(915203-500mg)
PEGPCL-H(912549-500mg)
PEGPCL-UH (917788-500mg)
Stabilizer-Nano (907766-5g)
application(s)
advanced drug delivery
storage temp.
2-8°C
General description
NanoFabTx™ PEG-PCL drug loading screening kit is a ready-to-use nanoformulation kit for the synthesis of PEGylated PCL nanoparticles 50 to 130 nm in size. This kit provides properly selected PEGylated PCL polymers, stabilizer, and protocols for the synthesis of drug-encapsulating nanoparticles by nanoprecipitation and microfluidic methods. Three different PEGylated PCLs are included in this kit, allowing rapid screening of optimal materials for enhancing drug loading. Protocols for two different particle synthesis methods are included.
- A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
- A Microfluidics protocol using commercial platforms or syringe pumps.
Application
NanoFabTx™ nanoformulation reagent kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery. Poly (ethylene glycol)-block-poly(caprolactone) (PEG-PCL) is a biocompatible and biodegradable polymer that has been approved by the FDA and the EMA for biomedical and pharmaceutical applications. PEG-PCL based nanoparticles have been widely used as drug delivery systems for different types of therapeutic molecules, to achieve controlled drug release. PEG-PCL nanoparticles offer a slow degradation rate, ideal for long-term implantation and sustained release. And unlike other polymer materials, PEG-PCL does not produce acidic byproducts upon degradation.
Features and Benefits
- Ready-to-use nanoformulation kit for PEGylated PCL nanoparticles
- Choose from either nanoprecipitation or microfluidics-based protocols
- Create specifically sized, biodegradable, PEGylated PCL nanoparticles
- Maximize the encapsulation of hydrophobic drugs
- Three different PEGylated PCLs are included
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
保管分類
10 - Combustible liquids
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
918881-1KT: + 918881-VAR: + 918881-BULK: + 918881-1EA:
jan
資料
フラッシュナノ沈殿（Flash NanoPrecipitation, FNP）は高充填ナノ粒子を作製する新たな方法として2003年に報告され、物のカプセル化から農薬の送達までさまざまな分野に影響を与えています。
NanoFabTx™プラットフォームは、すぐに使用できる製剤と粒子合成のためのマイクロ流体デバイスにより、薬剤開発を加速させます。
NanoFabTXキットは、mRNAや核酸用の脂質ナノ粒子やリポソームによる正確な薬物送達を可能にします。